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Ratnawati Ratnawati
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Journal : Paediatrica Indonesiana

 1 
Exhaled nitric oxide in acute exacerbation of pediatric asthma Ratnawati Ratnawati; V Nguyen; J Morton; R L Henry; P S Thomas
Paediatrica Indonesiana Vol 48 No 2 (2008): March 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.627 KB) | DOI: 10.14238/pi48.2.2008.64-70

Abstract

Background Measurement of exhaled nitric oxide (eNO) is a non-invasive and easy method to monitor airway inflammation.Objectives To compare the levels of eNO during and after anexacerbation of asthma, to evaluate the effect of glucocor-ticosteroids (GCS) on the levels of eNO and to correlate eNOwith other markers of inflammation such as symptom scores, FEV 1and sputum eosinophils.Methods The observational study was performed over 24 monthsat a tertiary paediatric hospital. Subjects underwent eNOmeasurement, spirometry and sputum induction during an asthmaexacerbation and then two weeks later. A symptom score wasrecorded everyday for two weeks. All subjects were treated withß 2 -adrenergic agonists and an oral glucocorticosteroid (GCS).Results Fifteen subjects with acute asthma exacerbation aged 5and 16 years old participated in the study. The mean level ofeNO during the acute exacerbation was significantly higher thaneNO levels at the follow-up visit, 11.2 (95%CI 9.2;13.2) vs. 8.0(95%CI 5.0;11.1) ppb, P=0.03. In the acute exacerbation, eNOcorrelated with sputum eosinophils (P=0.04), but no correlationcould be found between eNO and the other markers ofinflammation during exacerbation or follow up.Conclusions eNO level increased during asthma exacerbation anddecreased after two weeks of glucocorticosteroid therapy.Measurement of eNO is a practical monitoring method inemergency management of asthmatic children.
Co-Authors Agus Purwanto Ahmad Arif Ahmad Swandi Ahmad Yani Ali Djamhuri Amalia, Faradiba Amini, Rif'atul Andi Nurfitriani Andi Rustandi Anggriani, Ruci Aniek Sri Handayani Aniek Sri Handayani Arman Ahmad Aryadi Suwono Aryadi Suwono Asiyah Mumtahanah Khoiruzzahra Askar Askar Asmawati Asmawati Batau, ST. Haliah Budiwati Budiwati Buraerah, Muh. Fikruddin Cintha Ayu Wandira Damin Hartono Decy Lukitasari Didih Faridah, Didih Djukri Djukri Elis Sofianti Elvi Nurridho Khasanah Enda Puspitasari Eny Syatriana EVILIA YULIANI Faisal Yunus Fajrul Falah Fenny Roshayanti Fitri, Alchonity Harika H.M Samudro Halijah, Sitti Hasanah Fajar Sayekti Hilda Afrianti Bahri Hudriati, Andi Ika Nur Rahma Ikelis Safitri Iyus Hendrawan J Morton Jannah, Hariratul Jerniati I. Joko Siswanto Kaharuddin Kaharuddin Kasman Jaya Kevin Gabryelle Kolewora, Yusuf Musafir Kusumah, Rita La Harudu Latukau, Hasni Livana PH Livana Ph, Livana M Khairul Ardi Maryatul Qibtiyah Mashud Mashud MEDTRY, Medtry Mega utami kusumawati Mia Andinawati Moh Rosyid Mahmudi Mohamad Djaeni Muhammad Fadil Alif Ramadhan Muhammad Fajar Fathu Rhohman muhammad irfan Musayyedah Musayyedah Mutiara Eka Puspita nanang nanang Nanang Nanang Nensi Nur Astari Nika Cahyati Nur Rifai Akhsan Nuradnin Rizkiani Nurani, Desi Nurinda Sari Nurlina Nurlina Nurrrahmi, Maftuhah Nursyahid Siregar Nurul Miftakhul Jannah P S Thomas Perak Samosir Putrisari Putrisari R L Henry Rahma Ayu Maharani Ratnasari Ratnasari Rhoito Frista Rida Perwita Sari Riskawati Riskawati, Riskawati Rosa M Ros Rustam Tahir Said Mirza Pahlevi Salam, Rusdiah Saludung, Jokebet Samudro, H.M Sariman, Syahrul satriani satriani SATRIYAS ILYAS Setyorini Setyorini Silalahi, Oberlin Sitti Fatimah Sitti Inderiati Slamet . Slamet Suyanto Sri Sudewi Sry Rahayu Sugeng, Purwito Suhartini Suhartini Sukarni Hidayati Suratsih Suratsih Surdin, Surdin Suryani Yuliyanti, Suryani Taufik Hidayat Tavip Dwi Wahyuni Thoyyibah, Luthfiyatun Tien Aminatun Tismi Dipalaya, Tismi Ulfa Ramadhani Nasution V Nguyen Wahyudin Wenny Pebrianti Yano Hurung Anoi Yenny Widianty Yudhiakto Pramudya yumni, andi Yumriani Yumriani Yuni Wibowo Zulkifli N